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Bare hos et mindretall er det funnet kjente sykdommer som kan medføre langvarig smerte, for eksempel artrose, revmatiske sykdommer eller nervelidelser.Opptak gjennom huden Opptak gjennom huden kan skje med medisinsk plaster. Her er det to forskjellige grupper: den ene er plaster som inneholder medikament (lokalbedøvelse eller capsaicin) som virke
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